Yes, you can wreck an inertia pulled fast trying to pull 40 gr bullets from a 22-250. The 405 in the 45/70 pull with a couple of taps. I have hopes of better accuracy and easier bullet pulling once my Sinclair neck turned gets here and I determine the correct neck size collect for my RCBS Gold Medal Match die. My current best guess is .013 neck thickness and .289 neck collet for my 6.5 cartridges.