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Message: <blockquote data-quote="KDM" data-source="post: 441377" data-attributes="member: 314">Hey BrockW.  This is also direct from the USDA National Veterinary Accreditation Program dated March 20, 2024:I will highlight the interesting part. <h2>Testing</h2>Currently, definitive diagnosis is based on IHC testing of the obex area of the brain stem or the medial retropharyngeal lymph nodes. Gross lesions seen at necropsy reflect the clinical signs of CWD, primarily emaciation and sometimes aspiration pneumonia, which may be the primary (acute?) cause of death. On microscopic examination, lesions of CWD in the central nervous system resemble those of other spongiform encephalopathies. At this time, abnormal prion proteins can be detected using immunohistochemistry (IHC), Western blotting, enzyme-linked immunosorbent assay (ELISA), prion misfolding cyclic amplification (PMCA), and real-time quaking induced conversion (RT-QuIC), however, approved diagnostic assays are limited to IHC and ELISA. Research is being conducted to develop live-animal diagnostic tests for CWD. The rectal biopsy test, while not yet approved for routine regulatory testing, appears promising but may have limited applicability due the number of positive animals in the early stages of the disease that may not be detected. So which is it?  Yes they have approved live animal diagnostic tests or No, they don't have live animal tests?</blockquote>