When I shot a lot of 22-250 I mean a lot, 3000 to 6000 rounds per summer I used IMR 4895, 31 1/2 grains and Speer V-MAX 50 grain CCI large rifle primers Flew down the road right at 3200 feet per second. Tuned the rifles in to that slower speed to save on barrel life and shot a lot cooler. P-Dogs...