If one is shooting a 223/Wylde/5.56, at least 1:8, and tied to a magazine @ 2.26", the 53 V-Max is pretty much the most BC and Velocity one it going to be able to tie together within those confines. @ 16", ~3100fps is about all you're gonna get. @ 20" and longer, 3300-3350ish.
If a person has several 223's and maybe a few are 1:12-1:14 twist, 53 V-Max's probably aren't your best choice unless you're OK loading multiple projectiles for multiple rifles. The 50 V-Max and/or 55gn Soft-point are both excellent "do-all" choices if one is trying to have 1 load for multiple rifles with twist rates from "fast" to "standard".
I don't think I've ever used the 55 Sierra but if 'Bucks and 'Dogs are OK w/them, I'd have 0 issue giving them a whirl too.