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Message: <blockquote data-quote="Davy Crockett" data-source="post: 427718" data-attributes="member: 367">A couple things that stuck out in my head about synthetics after seeing them posted often are.....<a href="https://en.wikipedia.org/wiki/Synthetic_cannabinoids" target="_blank">https://en.wikipedia.org/wiki/Synthetic_cannabinoids</a>"Researchers have pointed out a few ways that synthetic cannabinoids differ from marijuana, and therefore may be more dangerous. First, they often have greater <a href="https://en.wikipedia.org/wiki/Intrinsic_activity" target="_blank">intrinsic activity</a>. Many of the synthetic cannabinoids are full <a href="https://en.wikipedia.org/wiki/Agonist" target="_blank">agonists</a> of the <a href="https://en.wikipedia.org/wiki/Cannabinoid_receptor" target="_blank">cannabinoids receptors</a>, <a href="https://en.wikipedia.org/wiki/Cannabinoid_receptor_type_1" target="_blank">CB1</a> and <a href="https://en.wikipedia.org/wiki/Cannabinoid_receptor_type_2" target="_blank">CB2</a>, compared to <a href="https://en.wikipedia.org/wiki/Tetrahydrocannabinol" target="_blank">THC</a>, which is only a <a href="https://en.wikipedia.org/wiki/Partial_agonist" target="_blank">partial agonist</a>.<a href="https://en.wikipedia.org/wiki/Synthetic_cannabinoids#cite_note-66" target="_blank">[66]</a>""  That tells me that even experienced users are at the same risk as a first time user.   Or probably more if they smoke the usual amount as they would with natural and get all messed up.    That and two different brands could do the exact opposite, who knows what might be in unregulated products ?   <a href="https://en.wikipedia.org/wiki/Adverse_effects" target="_blank">Adverse effects</a> observed due to synthetic cannabinoid use include <a href="https://en.wikipedia.org/wiki/Acute_kidney_injury" target="_blank">acute kidney injury</a>, <a href="https://en.wikipedia.org/wiki/Cardiac_toxicity" target="_blank">cardiac toxicity</a>, <a href="https://en.wikipedia.org/wiki/Seizure" target="_blank">seizure</a>, <a href="https://en.wikipedia.org/wiki/Stroke" target="_blank">stroke</a>, <a href="https://en.wikipedia.org/wiki/Tremor" target="_blank">tremor</a>, <a href="https://en.wikipedia.org/wiki/Hypokalemia" target="_blank">hypokalemia</a>, and <a href="https://en.wikipedia.org/wiki/Rhabdomyolysis" target="_blank">rhabdomyolysis</a>.<a href="https://en.wikipedia.org/wiki/Synthetic_cannabinoids#cite_note-Khullar-56" target="_blank">[56]</a><a href="https://en.wikipedia.org/wiki/Synthetic_cannabinoids#cite_note-57" target="_blank">[57]</a><a href="https://en.wikipedia.org/wiki/Synthetic_cannabinoids#cite_note-58" target="_blank">[58]</a><a href="https://en.wikipedia.org/wiki/Synthetic_cannabinoids#cite_note-59" target="_blank">[59]</a><a href="https://en.wikipedia.org/wiki/Synthetic_cannabinoids#cite_note-Fattore-60" target="_blank">[60]</a><a href="https://en.wikipedia.org/wiki/Synthetic_cannabinoids#cite_note-61" target="_blank">[61]</a> Some negative effects of <a href="https://en.wikipedia.org/wiki/5F-PB-22" target="_blank">5F-PB-22</a> reported by users included <a href="https://en.wikipedia.org/wiki/Nausea" target="_blank">nausea</a>, <a href="https://en.wikipedia.org/wiki/Vomiting" target="_blank">vomiting</a>, <a href="https://en.wikipedia.org/wiki/Confusion" target="_blank">confusion</a>, <a href="https://en.wikipedia.org/wiki/Ataxia" target="_blank">poor coordination</a>, <a href="https://en.wikipedia.org/wiki/Anxiety" target="_blank">anxiety</a>, and seizures. Some of the negative effects of <a href="https://en.wikipedia.org/wiki/5F-APINACA" target="_blank">5F-AKB-48</a> reported by users included <a href="https://en.wikipedia.org/wiki/Palpitations" target="_blank">palpitations</a>, <a href="https://en.wikipedia.org/wiki/Paranoia" target="_blank">paranoia</a>, intense anxiety, and a taste like burned plastic.<a href="https://en.wikipedia.org/wiki/Synthetic_cannabinoids#cite_note-:4-12" target="_blank">[12]</a> In addition, while there are no fatal <a href="https://en.wikipedia.org/wiki/Drug_overdose" target="_blank">overdose</a> cases linked to <a href="https://en.wikipedia.org/wiki/Cannabis_(drug)" target="_blank">marijuana</a>,<a href="https://en.wikipedia.org/wiki/Synthetic_cannabinoids#cite_note-62" target="_blank">[62]</a> there are deaths linked to synthetic cannabinoids each year.<a href="https://en.wikipedia.org/wiki/Synthetic_cannabinoids#cite_note-:11-14" target="_blank">[14]</a><a href="https://en.wikipedia.org/wiki/Synthetic_cannabinoids#cite_note-63" target="_blank">[63]</a><a href="https://en.wikipedia.org/wiki/Synthetic_cannabinoids#cite_note-64" target="_blank">[64]</a> The most common mechanisms leading to death following synthetic cannabinoid use include behavioral risks, such as self-harm and <a href="https://en.wikipedia.org/wiki/Suicide" target="_blank">suicide</a>, falling from a height, and wandering into traffic; <a href="https://en.wikipedia.org/wiki/Circulatory_system" target="_blank">cardiovascular</a> effects; and <a href="https://en.wikipedia.org/wiki/Central_nervous_system_depression" target="_blank">central nervous system depression</a>.<a href="https://en.wikipedia.org/wiki/Synthetic_cannabinoids#cite_note-65" target="_blank">[65]</a>.</blockquote>

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