2x6 is easier to insulate and gonna last longer, your doors are gonna work better longer etc, if its on a good slab with a thickened edge etc.,but, none of us have a money-tree in the backyard.so, I guess build what fits your budget if I was gonna build a pole shed for myself I would plan on spending about 2.50 a square foot for spray foam on walls, maybe you won't heat it...then you'd prob save quite a bit with a pole building because you woulden't have to finish the inside or hang liner panel on the ceiling so you can blow in insulation, if you didn't want to and theres quite a bit less lumber.if you wanna wait to pour the floor in the shop til you save up some more cash, then you would want a pole. pole buildings are considerably cheaper. I would stay away from 8 foot on center rafters, someone might give you a really good material bid and that might be one of the reasons why it is much cheaper.. I guess if I could afford it i'd go 2x6. I would absolutely go with floor heat if you plan to heat it though. of course,are you talkin 32x40 or 60x120? that will probably be the biggest influence in you decision.