Davey, you mentioned cannabinoid receptors within the human body. I'm curious, what receptor site within the body is being stimulated by the synthetic drugs you've mentioned?
Is there a list of substances (drugs, medication, foods, homeopathics, vitamins, supplements) that stimulate (agonist or antagonist) the cannabinoid receptors?
A couple things that stuck out in my head about synthetics after seeing them posted often are.....
https://en.wikipedia.org/wiki/Synthetic_cannabinoids
"Researchers have pointed out a few ways that synthetic cannabinoids differ from marijuana, and therefore may be more dangerous. First, they often have greater
intrinsic activity. Many of the synthetic cannabinoids are full
agonists of the
cannabinoids receptors,
CB1 and
CB2, compared to
THC, which is only a
partial agonist.
[66]""
That tells me that even experienced users are at the same risk as a first time user. Or probably more if they smoke the usual amount as they would with natural and get all messed up. That and two different brands could do the exact opposite, who knows what might be in unregulated products ?
Adverse effects observed due to synthetic cannabinoid use include
acute kidney injury,
cardiac toxicity,
seizure,
stroke,
tremor,
hypokalemia, and
rhabdomyolysis.
[56][57][58][59][60][61] Some negative effects of
5F-PB-22 reported by users included
nausea,
vomiting,
confusion,
poor coordination,
anxiety, and seizures. Some of the negative effects of
5F-AKB-48 reported by users included
palpitations,
paranoia, intense anxiety, and a taste like burned plastic.
[12] In addition, while there are no fatal
overdose cases linked to
marijuana,
[62] there are deaths linked to synthetic cannabinoids each year.
[14][63][64] The most common mechanisms leading to death following synthetic cannabinoid use include behavioral risks, such as self-harm and
suicide, falling from a height, and wandering into traffic;
cardiovascular effects; and
central nervous system depression.
[65]
.